Hi Mary,
There are multiple reasons your device may not be responding to your power cord causing it not to charge, a number of which are listed on our[[Garmin Nuvi 2595LMT Troubleshooting#Section_Battery_Will_Not_Charge|troubleshooting page]].
First, make sure your charging cable is securely plugged into your vehicle and that your vehicle is also turned on. It may be that your power cable fuse is no longer functional, and you'll need to purchase a new one.
If you leave your device in your vehicle for an extended period of time, it may have overheated or gotten too cold, and can only operate between 32 degrees Fahrenheit and 113 degrees Fahrenheit.
Hopefully this helps answer your question,
-Ellidie