You have to restart the computer and after restart the computer, It would be work and after restarting if mouse doesn't work so.. You have to update the drivers . for additional steps visit '''FIX-mouse-not-working-in-computer''' Follow these Steps: a) Press the Windows + R key on the keyboard. b) Type devmgmt.msc in search box and click on OK c) Right Click on Mice and other pointing device d) Click on update drives then click on Search automatically Then restart the computer. After that Mouse doesn't working So: Then try to change USB port of Mouse. Please let me know for any other issue .